50% of players drafted in the second round had USL League Two playing experience.
Pick |
 |
MLS |
Player |
Year* |
|
| 1 | Orange County SC U23 |
 |
Charlotte FC |
Kyle Holcomb | 2019 |
| 2 | Green Bay Voyageurs |
|
FC Cincinnati |
Nicholas Markanich | 2021 |
| 4 | Boston Bolts |
|
Houston Dynamo |
Paulo Lima | 2019 |
| 6 | New York Red Bulls U23 |
|
New York City FC |
Kevin O'Toole | 2021 |
| 8 | Portland Timbers U23 |
|
DC United |
Sofiane Djeffal | 2019 |
| 10 | Florida Elite SC |
|
Nashville SC |
Will Meyer | 2021 |
| 12 | Flint City Bucks |
|
Columbus Crew |
Jacob Erlandson | 2021 |
| 15 | Chicago FC United |
|
Seattle Sounders FC |
Achille Robin | 2021 |
| 18 | Sounders FC U23 |
|
Orlando City SC |
Nathan Dossantos | 2019 |
| 20 | Flint City Bucks |
|
Inter Miami CF |
Justin Ingram | 2019 |
| 21 | FC Golden State Force |
|
Vancouver Whitecaps |
Giovanni Aguilar | 2019 |
| 25 | FC Golden State Force |
|
Real Salt Lake |
Pedro Fonseca | 2018 |
| 26 | Boston Bolts |
|
Inter Miami CF |
Tyler Bagley | 2021 |
| 28 | Des Moines Menace |
|
New York City FC |
Kingsford Adjei | 2021 |